Co-delivery of proapoptotic peptide and p53 DNA by reduction-sensitive polypeptides for cancer therapy1. (21st May 2015)

• Record Type: Journal Article
• Authors: Chen, Si; Rong, Lei; Jia, Hui-Zhen; Qin, Si-Yong; Zeng, Xuan; Zhuo, Ren-Xi; Zhang, Xian-Zheng
• Is Part Of: Biomaterials science. Volume 3:Number 5(2015:May)
• Page Start: 753
• Page End: 763
• Publication Date: 2015-05-21
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1039/c5bm00046g
• Languages: English
• ISSNs: 2047-4830

Abstract

<abstract abstract-type="toc"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <graphic position="anchor" id="ga" xlink:href="ark:/27927/pgjn26w3mt" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" />The xPolyR₈–KLA(TPP)/p53 complex releases the p53 gene and C-KLA(TPP) in the cytoplasm, and initiates a more efficient cell apoptosis due to the regulation of both apoptotic pathways through p53 and C-KLA(TPP).</p> </abstract>