Extent of secondary intraventricular hemorrhage is an independent predictor of outcomes in intracerebral hemorrhage: data from the Helsinki ICH Study. Issue 4 (12th January 2015)

• Record Type: Journal Article
• Authors: Mustanoja, Satu; Satopää, Jarno; Meretoja, Atte; Putaala, Jukka; Strbian, Daniel; Curtze, Sami; Haapaniemi, Elena; Sairanen, Tiina; Niemelä, Mika; Kaste, Markku; Tatlisumak, Turgut
• Is Part Of: International journal of stroke. Volume 10:Issue 4(2015:Jun.)
• Page Start: 576
• Page End: 581
• Publication Date: 2015-01-12
• Subjects: 616.8005
• DOI: 10.1111/ijs.12437
• Languages: English
• ISSNs: 1747-4930

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ijs12437-sec-0001" sec-type="section"> <title>Background</title> <p>Intraventricular hemorrhage is a severe subtype of intracerebral hemorrhage associated with high mortality and poor outcome.</p> </sec> <sec id="ijs12437-sec-0002" sec-type="section"> <title>Aim</title> <p>We analyzed various intraventricular hemorrhage scores at baseline to find common parameters associated with increased mortality.</p> </sec> <sec id="ijs12437-sec-0003" sec-type="section"> <title>Methods</title> <p>Consecutive intracerebral hemorrhage patients treated in Helsinki University Central Hospital during 2005–2010 were included in the Helsinki Intracerebral Hemorrhage Study registry and analyzed for three‐month mortality.</p> </sec> <sec id="ijs12437-sec-0004" sec-type="section"> <title>Results</title> <p>After excluding lost‐to‐follow‐up patients, 967 intracerebral hemorrhage patients were included, out of whom 398 (41%) had intraventricular hemorrhage. Intraventricular hemorrhage patients, compared with nonintraventricular hemorrhage patients, had lower baseline Glasgow Coma Scale [median 12 (IQR 6–15) vs. 15 (13–15); <italic>P</italic> < 0·001] and higher National Institutes of Health Stroke Scale [18 (10–27) vs. 7 (3–14); <italic>P</italic> < 0·001] scores; larger intracerebral hemorrhage volumes [17 ml (7·2–42) vs. 6·8 (2·4–18); <italic>P</italic> < 0·001] and more often hydrocephalus (51% vs. 9%; <italic>P</italic> < 0·001); and higher mortality rates (54% vs. 18%; <italic>P</italic> < 0·001). In multivariable analysis, the presence of intraventricular hemorrhage was independently associated with mortality [OR 2·05 (95% CI 1·36–3·09)] when adjusted for well‐known prognostic factors of intracerebral hemorrhage, i.e. age, gender, baseline National Institutes of Health Stroke Scale, intracerebral hemorrhage volume, infratentorial location, and etiology.</p> </sec> <sec id="ijs12437-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The presence of intraventricular hemorrhage was independently associated with increased mortality, and all the intraventricular hemorrhage scores were strong predictors of three‐month mortality.</p> </sec> </abstract>