Host Nonresponsiveness Does not Interfere With Vaccine‐Mediated Protection Against Gastric Helicobacter Infection. Issue 3 (15th February 2015)

• Record Type: Journal Article
• Authors: Harbour, Stacey N.; Mitchell, Hazel M.; Sutton, Philip
• Is Part Of: Helicobacter. Volume 20:Issue 3(2015:Jun.)
• Page Start: 217
• Page End: 222
• Publication Date: 2015-02-15
• Subjects: Helicobacter -- Periodicals; Helicobacter infections -- Periodicals; Stomach -- Diseases -- Periodicals; 616.3301405
• DOI: 10.1111/hel.12197
• Languages: English
• ISSNs: 1083-4389

Abstract

<abstract abstract-type="main" id="hel12197-abs-0001"> <title>Abstract</title> <sec id="hel12197-sec-0001" sec-type="section"> <title>Background</title> <p> <italic>Helicobacter pylori</italic> pathogenesis results from the inflammation induced by chronic infection. CBA mice are nonresponsive to gastric <italic>Helicobacter</italic> infection, providing a useful model for examining host regulation of <italic>Helicobacter</italic>‐induced gastritis. We examined whether gastric <italic>Helicobacter</italic> nonresponsiveness impacts upon vaccine efficacy and whether immune‐mediated protection could occur in the absence of inflammation.</p> </sec> <sec id="hel12197-sec-0002" sec-type="section"> <title>Methods</title> <p>Mice were vaccinated prior to challenge with <italic>Helicobacter felis</italic> or <italic>H. pylori</italic>. Gastritis and <italic>H. felis</italic> colonization was evaluated histologically. <italic>H. pylori</italic> colonization was quantified by colony‐forming assay.</p> </sec> <sec id="hel12197-sec-0003" sec-type="section"> <title>Results</title> <p>Immunizations protected CBA mice against challenge with either <italic>H. felis</italic> or <italic>H. pylori</italic>. Protection against <italic>H. felis</italic> was marked by a loss of nonresponsiveness and development of an atrophic gastritis with mucus metaplasia. However, vaccine‐induced protection against <italic>H. pylori</italic> was only associated with cell infiltration into the gastric mucosa.</p> </sec> <sec id="hel12197-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Nonresponsiveness to gastric <italic>Helicobacter</italic> infection did not interfere with vaccination‐induced protection. Vaccine‐induced protective immunity against <italic>H. pylori</italic> was linked with the induction of cellular infiltration, but importantly not atrophic gastritis.</p> </sec> </abstract>