Immunotherapy: An Iron Oxide Nanocarrier Loaded with a Pt(IV) Prodrug and Immunostimulatory dsRNA for Combining Complementary Cancer Killing Effects (Adv. Healthcare Mater. 7/2015). Issue 7 (May 2015)

• Record Type: Journal Article
• Authors: Hernández‐Gil, Javier; Cobaleda‐Siles, Macarena; Zabaleta, Aintzane; Salassa, Luca; Calvo, Javier; Mareque‐Rivas, Juan C.
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 7(2015)
• Page Start: 1106
• Page End: 1106
• Publication Date: 2015-05
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201570044
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adhm201570044-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Micelles filled with iron oxide nanoparticles (IONPs) with a size suitable for effective lymphatic delivery are loaded with a cisplatin Pt(IV) prodrug and a immunostimulatory dsRNA (poly (I:C)) to provide targeted chemoimmunotherapy. On page 1034, J. C. Mareque‐Rivas and colleagues show that, compared to the free drugs, the poly (I:C)‐Pt(IV)‐IONPs exhibit greatly enhanced cancer cell killing properties and ability to activate dendritic cells. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjn22rwhx" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>