Chlorhexidine gluconate versus povidone iodine at cesarean delivery: a randomized controlled trial. (March 2015)

• Record Type: Journal Article
• Authors: Kunkle, Cynelle M.; Marchan, Jennifer; Safadi, Sara; Whitman, Stephanie; Chmait, Ramen H.
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 28:Number 5(2015)
• Page Start: 573
• Page End: 577
• Publication Date: 2015-03
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2014.926884
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background/Aims</italic>: To compare the prevalence of positive bacterial cultures at the cesarean delivery (CD) incision site in patients with pre-operative application of chlorhexidine gluconate (CG) versus povidone iodine (PI).</p> <p> <italic>Methods</italic>: Women undergoing a scheduled CD at ≥36 gestational weeks were randomly assigned to receive CG or PI. A swab of the incision site was performed at 3 min after disinfectant application and at 18 post-operative hours, and the prevalence of cultures with any detected bacterial growth was compared for the two groups.</p> <p> <italic>Results</italic>: Of the 60 participants, 33 (55.0%) were in the PI group. There were no differences detected at 3 min, with 9.1% positive in the PI group versus 0% positive in the CG group (<italic>p</italic> = 0.2499). However, at 18 h, women in the PI group were seven times more likely than women in the CG group to have a positive culture (16/33 [48.5%] versus 3/27 [11.1%], OR = 7.53 [95% CI 1.67–38.83], <italic>p</italic> = 0.0023). Multivariate logistic regression demonstrated similar results: OR = 7.33 (95% CI 1.77–30.35), <italic>p</italic> = 0.0060.</p> <p> <italic>Conclusion</italic>: The prevalence of positive bacterial cultures obtained at the site of the skin incision 18 h after CD was higher in the PI versus the CG group.</p> </abstract>