Perinatal outcomes of women with a prior history of unexplained recurrent miscarriage. (March 2015)

• Record Type: Journal Article
• Authors: Dempsey, Mark A.; Flood, Karen; Burke, Naomi; Fletcher, Patricia; Kirkham, Colin; Geary, Michael P.; Malone, Fergal D.
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 28:Number 5(2015)
• Page Start: 522
• Page End: 525
• Publication Date: 2015-03
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2014.923394
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: We sought to determine subsequent pregnancy outcomes in a cohort of women with a history of unexplained recurrent miscarriage (RM) who were not receiving medical treatment.</p> <p> <italic>Study design</italic>: This was a prospective cohort study, of women with a history of three unexplained consecutive first trimester losses, who were recruited and followed in their subsequent pregnancy. Control patients were healthy pregnant patients with no previous adverse perinatal outcome.</p> <p> <italic>Results</italic>: A total of 42 patients with a history of unexplained RM were recruited to the study. About nine (21.4%) experienced a further first trimester miscarriage, one case of ectopic and one case of partial molar pregnancy. About 74% (23/31) of the RM cohort had a vaginal delivery. There was one case of severe pre-eclampsia. The RM group delivered at a mean gestational age of 38 + 2 weeks and with a mean birthweight of 3.23 kg. None of the neonates were under the 10th centile for gestational age. Overall, there was no significant difference in pregnancy outcomes between the two cohorts.</p> <p> <italic>Conclusion</italic>: Our study confirms the reassuring prognosis for achieving a live birth in the unexplained RM population with a very low incidence of adverse events with the majority delivering appropriately grown fetuses at term.</p> </abstract>