Regulatory T cell differentiation: cooperation saves the day. (24th February 2015)

• Record Type: Journal Article
• Authors: Liston, Adrian; Schlenner, Susan M
• Is Part Of: EMBO journal. Volume 34:Number 9(2015)
• Page Start: 1145
• Page End: 1146
• Publication Date: 2015-02-24
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.201591169
• Languages: English
• ISSNs: 0261-4189

Abstract

<abstract abstract-type="main" id="embj201591169-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p content-type="executiveSummary">MicroRNA are important regulators of CD4 T cell differentiation, altering the balance between the immunogenic and tolerogenic pathways. Studies in mice with microRNA‐deficient T cells have revealed defects in differentiation into the regulatory T cell lineage; however, the individual microRNA responsible have remained elusive. A recent paper in <italic>The EMBO Journal</italic> uses a systematic screen to find a novel cooperative action between an inducible and a constitutive microRNA in aiding regulatory T cell induction.</p> </abstract>