Type 1 and type 2 autoimmune hepatitis in adults share the same clinical phenotype. Issue 12 (19th April 2015)

• Record Type: Journal Article
• Authors: Muratori, P.; Lalanne, C.; Fabbri, A.; Cassani, F.; Lenzi, M.; Muratori, L.
• Is Part Of: Alimentary pharmacology & therapeutics. Volume 41:Issue 12(2015)
• Page Start: 1281
• Page End: 1287
• Publication Date: 2015-04-19
• Subjects: Digestive organs -- Diseases -- Treatment -- Periodicals; Digestive organs -- Effect of drugs on -- Periodicals; Gastrointestinal system -- Diseases -- Treatment -- Periodicals; Gastrointestinal system -- Effect of drugs on -- Periodicals; 615.73
• DOI: 10.1111/apt.13210
• Languages: English
• ISSNs: 0269-2813

Abstract

<abstract abstract-type="main" id="apt13210-abs-0001"> <title>Summary</title> <sec id="apt13210-sec-0001" sec-type="section"> <title>Background</title> <p>Autoimmune hepatitis (AIH) is historically classified into type 1 and type 2 on the basis of the autoantibody profile, anti‐nuclear and/or anti‐smooth muscle antibodies being the serological markers of type 1 AIH, whereas anti‐liver/kidney microsomal antibody type 1 and/or anti‐liver cytosol antibody type 1 characterise type 2 AIH.</p> </sec> <sec id="apt13210-sec-0002" sec-type="section"> <title>Aim</title> <p>To evaluate whether such a distinction is justified on the basis of different expression of the disease in adults.</p> </sec> <sec id="apt13210-sec-0003" sec-type="section"> <title>Methods</title> <p>Twenty‐six adult patients with type 2 AIH and 52 age‐ and sex‐matched patients with type 1 AIH, representative of the entire cohort of adults with type 1 AIH, were compared at onset and during follow‐up.</p> </sec> <sec id="apt13210-sec-0004" sec-type="section"> <title>Results</title> <p>At diagnosis, median age was 26 years (range 17–53), female sex 86%, acute presentation 43%, severe liver histology 54%, cirrhosis 14%, complete response to treatment 52%, progression of the disease 17%, and median disease duration 72 months (range 12–280). HLA‐DRB1*0301 was present in 26%, HLA‐DRB1*0401 in 23% and HLA‐DRB1*0701 in 25%. Clinical presentation, biochemical parameters, severe liver histology, genetic profile, response rate and progression of the disease were identical between type 1 and type 2 AIH.</p> </sec> <sec id="apt13210-sec-0005" sec-type="section"> <title>Conclusion</title> <p>There is not enough clinical, biochemical, histological or genetic reason to subdivide adults with autoimmune hepatitis into type 1 and type 2 on the basis of the autoantibody profile, and the term 'autoimmune hepatitis' without qualification should be preferred.</p> </sec> </abstract>