Distribution of cytokine gene polymorphisms in five Malay subethnic groups in Peninsular Malaysia. (21st March 2015)

• Record Type: Journal Article
• Authors: Norhalifah, H. K.; Zafarina, Z.; Sundararajulu, P.; Norazmi, M. N.; Edinur, H. A.
• Is Part Of: International journal of immunogenetics. Volume 42:Number 3(2015:Jun.)
• Page Start: 200
• Page End: 203
• Publication Date: 2015-03-21
• Subjects: Immunogenetics -- Periodicals; 571.9648
• DOI: 10.1111/iji.12189
• Languages: English
• ISSNs: 1744-3121

Abstract

<abstract abstract-type="main" id="iji12189-abs-0001"> <title>Summary</title> <p>In this survey, we have successfully genotyped 22 single nucleotide polymorphisms in the 13 cytokine genes for five Malay subethnic groups (Kelantan, Acheh, Mandailing, Minangkabau and Patani Malays) using polymerase chain reaction–sequence‐specific primer cytokine genotyping kit (Invitrogen, Carlsbad, CA, USA). Most of the cytokine genes showed similar pattern of allelic spectra with wild‐type alleles (e.g. <italic>ILIa−889/C, ILIB+3962/C</italic> and <italic>IL6 nt565/G</italic>) that represent more than 80% in the studied Malay subethnic groups. These newly observed cytokine alleles and subsequent analyses clearly indicate genetic contribution from Asia in the studied Malay subethnic groups with evidence of admixture from neighbouring populations in Patani Malays. The cytokine data sets for the five Malay subethnic groups deposited in this report can also be used as reference standard for searching suitable donor for allograft transplant and diseases association study. This is particularly relevance as our analyses showed differences between the Malay subethnic groups and other populations screened for cytokine genes.</p> </abstract>