Β3‐AR and the vertebrate heart: a comparative view. (6th April 2015)

• Record Type: Journal Article
• Authors: Imbrogno, S.; Gattuso, A.; Mazza, R.; Angelone, T.; Cerra, M. C.
• Is Part Of: Acta physiologica. Volume 214:Number 2(2015:Jun.)
• Page Start: 158
• Page End: 175
• Publication Date: 2015-04-06
• Subjects: Physiology -- Periodicals; Physiology -- Research -- Periodicals; 612
• DOI: 10.1111/apha.12493
• Languages: English
• ISSNs: 1748-1708

Abstract

<abstract abstract-type="main" id="apha12493-abs-0001"> <title>Abstract</title> <p>Recent cardiovascular research showed that, together with <italic>β</italic><sub>1</sub>‐ and <italic>β</italic><sub>2</sub>‐adrenergic receptors (ARs), <italic>β</italic><sub>3</sub>‐ARs contribute to the catecholamine (CA)‐dependent control of the heart. <italic>β</italic><sub>3</sub>‐ARs structure, function and ligands were investigated in mammals because of their applicative potential in human cardiovascular diseases. Only recently, the concept of a <italic>β</italic><sub>3</sub>‐AR‐dependent cardiac modulation was extended to non‐mammalian vertebrates, although information is still scarce and fragmentary. <italic>β</italic><sub>3</sub>‐ARs were structurally described in fish, showing a closer relationship to mammalian <italic>β</italic><sub>1</sub>‐AR than <italic>β</italic><sub>2</sub>‐AR. Functional <italic>β</italic><sub>3</sub>‐ARs are present in the cardiac tissue of teleosts and amphibians. As in mammals, activation of these receptors elicits a negative modulation of the inotropic performance through the involvement of the endothelium endocardium (EE), G<sub>i/0</sub> proteins and the nitric oxide (NO) signalling. This review aims to comparatively analyse data from literature on <italic>β</italic><sub>3</sub>‐ARs in mammals, with those on teleosts and amphibians. The purpose is to highlight aspects of uniformity and diversity of <italic>β</italic><sub>3</sub>‐ARs structure, ligands activity, function and signalling cascades throughout vertebrates. This may provide new perspectives aimed to clarify the biological relevance of <italic>β</italic><sub>3</sub>‐ARs in the context of the nervous and humoral control of the heart and its functional plasticity.</p> </abstract>