Interleukin-27 and interleukin-23 in patients with systemic lupus erythematosus: possible role in lupus nephritis. (May 2015)

• Record Type: Journal Article
• Authors: Xia, LP; Li, BF; Shen, H; Lu, J
• Is Part Of: Scandinavian journal of rheumatology. Volume 44:Number 3(2015)
• Page Start: 200
• Page End: 205
• Publication Date: 2015-05
• Subjects: Rheumatology -- Periodicals; Arthritis; Rheumatic Diseases; 616.72005
• DOI: 10.3109/03009742.2014.962080
• Languages: English
• ISSNs: 0300-9742

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Objectives:</bold> To analyse the concentration of interleukin (IL)-27 and IL-23 in serum and urine of patients with systemic lupus erythematosus (SLE) compared with healthy controls (HC).</p> <p> <bold>Method:</bold> An enzyme-linked immunosorbent assay (ELISA) was used to analyse the serum and urine concentration of IL-27 and IL-23 from 50 patients with lupus nephritis (LN), 55 patients without LN, and 30 HC. The correlations between the levels of IL-27, IL-23, and disease activity, clinical parameters in SLE patients were analysed.</p> <p> <bold>Results:</bold> The levels of IL-27 and IL-23 increased significantly in the serum and urine of SLE patients with and without LN compared with HC. Moreover, urine levels of IL-27 and IL-23 were correlated with the renal SLE Disease Activity Index (rSLEDAI) score and 24-h urinary protein levels. After 6 months of immunosuppressive treatment, urine IL-27 expression rose significantly in SLE patients with LN.</p> <p> <bold>Conclusions:</bold> IL-27 and IL-23 may be involved in the pathogenesis of LN.</p> </abstract>