Analysis of Nitric Oxide from Chemical Donors Using CMOS Platinum Microelectrodes. Issue 5 (20th February 2015)

• Record Type: Journal Article
• Authors: Feeny, Rachel M.; Wydallis, John B.; Chen, Tom; Tobet, Stuart; Reynolds, Melissa M.; Henry, Charles S.
• Is Part Of: Electroanalysis. Volume 27:Issue 5(2015:May)
• Page Start: 1104
• Page End: 1109
• Publication Date: 2015-02-20
• Subjects: Electrochemical analysis -- Periodicals; Chemistry, Analytical -- Periodicals; Electrochemistry -- Periodicals; 543.4
• DOI: 10.1002/elan.201400510
• Languages: English
• ISSNs: 1040-0397

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Electrochemical detection of NO generated from chemical donors is reported. Because NO is an important biological messenger, many donor sources and detection methods have been developed. Few reports have characterized NO donors using electrochemistry despite electrochemical techniques being sensitive and selective. Here, a CMOS platinum microelectrode array is interfaced with a microfluidic device for the electrochemical analysis of NO from (<italic>Z</italic>)‐1‐[<italic>N</italic>‐(2‐aminoethyl)‐<italic>N</italic>‐(2‐ammonioethyl)amino]diazen‐1‐ium‐1, 2‐diolate (DETA/NO). The donor parent amine fouls the electrode, resulting in substantial signal loss, but an electrochemical cleaning method was developed that substantially reduces fouling and allows detection of NO between 90 nM and 1 µM.</p> </abstract>