Light alcohol consumption plays a protective role against non‐alcoholic fatty liver disease in Japanese men with metabolic syndrome. (21st January 2015)

• Record Type: Journal Article
• Authors: Sogabe, Masahiro; Okahisa, Toshiya; Taniguchi, Tatsuya; Tomonari, Tetsu; Tanaka, Takahiro; Tanaka, Hironori; Nakasono, Masahiko; Takayama, Tetsuji
• Is Part Of: Liver international. Volume 35:Number 6(2015:Jun.)
• Page Start: 1707
• Page End: 1714
• Publication Date: 2015-01-21
• Subjects: Liver -- Periodicals; Liver -- Diseases -- Periodicals; 616.362
• DOI: 10.1111/liv.12754
• Languages: English
• ISSNs: 1478-3223

Abstract

<abstract abstract-type="main" id="liv12754-abs-0001"> <title>Abstract</title> <sec id="liv12754-sec-0001" sec-type="section"> <title>Background & Aims</title> <p>Although excess alcohol consumption has been believed to cause liver injury, light alcohol consumption (LAC) has been reported to play a protective role against fatty liver in recent studies. However, the association between non‐alcoholic fatty liver disease (NAFLD) and LAC in men with metabolic syndrome (MS) is unclear. The aim of this study was to examine the association between NAFLD and LAC in men with MS.</p> </sec> <sec id="liv12754-sec-0002" sec-type="section"> <title>Methods</title> <p>Subjects were 1055 men with MS who underwent a regular health check‐up and drank less 20 g/day of alcohol. A distinction was made between non‐drinkers and light drinkers and the association between NAFLD and LAC in men with MS was elucidated. NAFLD was referred as fatty liver with alanine aminotransferase (ALT) levels ≧31 IU/L in this study.</p> </sec> <sec id="liv12754-sec-0003" sec-type="section"> <title>Results</title> <p>Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and the prevalence of NAFLD were significantly lower in light drinkers than in non‐drinkers. Logistic regression analysis showed body mass index (BMI), waist circumference (WC), uric acid (UA), haemoglobin A1c (HbA1c), visceral fat type MS and LAC (odds ratios: 0.654; 95% confidence intervals: 0.473–0.906; <0.05) were significant predictors of the prevalence of NAFLD.</p> </sec> <sec id="liv12754-sec-0004" sec-type="section"> <title>Conclusion</title> <p>The prevalence of NAFLD in light drinkers was significantly lower than in non‐drinkers, and supporting previous reports studying the general population, LAC is one of the significant predictors of a decreased prevalence of NAFLD in men with MS.</p> </sec> </abstract>