Altered Brain White Matter Integrity in Temporal Lobe Epilepsy: A TBSS Study. Issue 3 (25th July 2014)

• Record Type: Journal Article
• Authors: Liu, Zhenyin; Xu, Yong; An, Jie; Wang, Junjing; Yin, Xiangyuan; Huang, Ruiwang; Lv, Xiaofei; Chen, Lina; Wang, Wensheng; Qiu, Shijun
• Is Part Of: Journal of neuroimaging. Volume 25:Issue 3(2015)
• Page Start: 460
• Page End: 464
• Publication Date: 2014-07-25
• Subjects: Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.12154
• Languages: English
• ISSNs: 1051-2284

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="jon12154-sec-0010" sec-type="section"> <title>BACKGROUND AND PURPOSE</title> <p>The aim of this study is to explore the possible changed cerebral white matter regions in patients with temporal lobe epilepsy (TLE) using diffusion tensor imaging (DTI) and tract‐based spatial statistics (TBSS).</p> </sec> <sec id="jon12154-sec-0020" sec-type="section"> <title>METHODS</title> <p>Twenty TLE patients and 22 age‐ and gender‐matched normal controls were included in this study. Voxel‐wise analyses of multiple diffusion metrics, including fractional anisotropy (FA) and mean diffusivity (MD) were performed with TBSS.</p> </sec> <sec id="jon12154-sec-0030" sec-type="section"> <title>RESULTS</title> <p>TLE patients exhibited significantly reduced FA in widespread white matter regions including bilateral limbic circuit, corpus callosum, thalamus, internal/external capsule, temporooccipital connections, frontotemporal connections; increase of MD was exhibited significantly almost in the left hemisphere. A significant decrease in global FA integrity was shown in epilepsy subjects compared to healthy controls. Furthermore, it exhibited a significant positive correlation between the disease duration and MD of whole brain.</p> </sec> <sec id="jon12154-sec-0040" sec-type="section"> <title>CONCLUSIONS</title> <p>TLE is associated with widespread abnormalities in cerebral white matter tracts and these changes may have important clinical consequences.</p> </sec> </abstract>