Crescentic glomerulonephritis: data from the Spanish Glomerulonephritis Registry. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Quiroga, B.; Vega, A.; Rivera, F.; López‐Gómez, J. M.; the Spanish Registry of Glomerulonephritis
• Is Part Of: Internal medicine journal. Volume 45:Issue 5(2015)
• Page Start: 557
• Page End: 562
• Publication Date: 2015-05
• Subjects: Medicine -- Periodicals; 616
• DOI: 10.1111/imj.12725
• Languages: English
• ISSNs: 1444-0903

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="imj12725-sec-0001" sec-type="section"> <title>Background</title> <p>Crescentic glomerulonephritis (CGN) is a histological finding that implies rapid deterioration of renal function and can be related to different diseases, such as type 1 or anti‐glomerular basement membrane antibody (Goodpasture) disease, type 2 or immune complex CGN and type 3 or pauci‐immune disease.</p> </sec> <sec id="imj12725-sec-0002" sec-type="section"> <title>Aim</title> <p>The present study describes CGN and its characteristics based on the data from the Spanish Glomerulonephritis Registry.</p> </sec> <sec id="imj12725-sec-0003" sec-type="section"> <title>Methods</title> <p>An analysis was made of all native renal biopsies obtained from patients during 1994–2013 and classified as CGN. A patient epidemiological and clinical data questionnaire was completed by the 120 centres involved.</p> </sec> <sec id="imj12725-sec-0004" sec-type="section"> <title>Results</title> <p>A total of 21 774 biopsies was performed, of which 2089 (8.1%) corresponded to CGN (211 type 1, 177 type 2 and 1701 type 3). Renal function was poorer in type 1 compared with types 2 and 3, and proteinuria was higher in type 2 compared to types 1 and 3. Patients diagnosed with CGN type 3 were older than those with types 1 and 2, but less hypertensive than the type 2 patients. No differences in the urine test findings were found between types 1 and 2. Microhaematuria was the most frequent feature in general, as well as in type 3 compared with types 1 and 2. The main indication for biopsy was acute renal injury. Age was the only difference between type 1 patients with and without alveolar haemorrhage (53 [33–67] vs 64 [46–73], <italic>P</italic> = 0.008).</p> </sec> <sec id="imj12725-sec-0005" sec-type="section"> <title>Conclusion</title> <p>Although classified as the same entity, the different types of CGN have different features that must be taken into account.</p> </sec> </abstract>