Apelin and G212A apelin receptor gene polymorphism in obese and diabese youth. Issue 3 (24th July 2014)

• Record Type: Journal Article
• Authors: Kotanidou, E. P.; Kalinderi, K.; Kyrgios, I.; Efraimidou, S.; Fidani, L.; Papadopoulou‐Alataki, E.; Eboriadou‐Petikopoulou, M.; Galli‐Tsinopoulou, A.
• Is Part Of: Pediatric obesity. Volume 10:Issue 3(2015:Jun.)
• Page Start: 213
• Page End: 219
• Publication Date: 2014-07-24
• Subjects: Obesity in children -- Periodicals; Obesity in adolescence -- Periodicals; Obesity -- Periodicals; Overweight children -- Periodicals; 618.92398
• DOI: 10.1111/ijpo.251
• Languages: English
• ISSNs: 1747-7174

Abstract

<abstract abstract-type="main"> <title>Summary</title> <sec id="ijpo251-sec-0001" sec-type="section"> <title>Objective</title> <p>The apelinergic system has been previously described to participate in fluid homeostasis, cardiac contractility, blood pressure and neo‐vascularization. The role of apelin in obesity and glucose metabolism has also lately gained interest; however, it still remains obscure. This study aimed to assess serum apelin levels in obese youngsters and to investigate any possible association with the G212A polymorphism of the apelin receptor (APLNR) gene.</p> </sec> <sec id="ijpo251-sec-0002" sec-type="section"> <title>Methods</title> <p>Ninety obese individuals and 90 matched for age and gender lean controls were included. Anthropometric measurements, data of glucose metabolism, including an oral glucose tolerance test, and serum apelin levels were obtained. The presence of the G212A polymorphism of the APLNR gene was also analyzed in the obese group.</p> </sec> <sec id="ijpo251-sec-0003" sec-type="section"> <title>Results</title> <p>Obese participants had significantly lower serum apelin levels as compared with controls (<italic>P</italic> = 0.011). After being grouped according to their status of glucose metabolism, only obese subjects with impaired glucose metabolism (diabese) exhibited lower apelin levels as compared with controls. The presence of the G212A polymorphism did not differ from the HapMap‐reported frequencies in Caucasians (GG = 53.3%/GA = 38.9%/ΑΑ = 7.8% vs. GG = 46.9%/GA = 39.8%/ΑΑ = 13.3%, <italic>P</italic> = 0.232). The GG and GA obese subgroups had significantly lower apelin levels as compared with the AA group (<italic>P</italic> = 0.013 and <italic>P</italic> = 0.016, respectively).</p> </sec> <sec id="ijpo251-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Obese (especially diabese) youngsters demonstrated lower serum apelin levels; the G212A polymorphism of the APLNR gene was found to exert a favourable effect on circulating apelin levels in childhood obesity.</p> </sec> </abstract>