A Signal‐Passing DNA‐Strand‐Exchange Mechanism for Active Self‐Assembly of DNA Nanostructures1. Issue 20 (24th March 2015)

• Record Type: Journal Article
• Authors: Padilla, Jennifer E.; Sha, Ruojie; Kristiansen, Martin; Chen, Junghuei; Jonoska, Natasha; Seeman, Nadrian C.
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 20(2015)
• Page Start: 5939
• Page End: 5942
• Publication Date: 2015-03-24
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201500252
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>DNA nanostructured tiles play an active role in their own self‐assembly in the system described herein whereby they initiate a binding event that produces a cascading assembly process. We present DNA tiles that have a simple but powerful property: they respond to a binding event at one end of the tile by passing a signal across the tile to activate a binding site at the other end. This action allows sequential, virtually irreversible self‐assembly of tiles and enables local communication during the self‐assembly process. This localized signal‐passing mechanism provides a new element of control for autonomous self‐assembly of DNA nanostructures.</p> </abstract>