Cover Picture: Reconstitution of Biosynthetic Machinery for the Synthesis of the Highly Elaborated Indole Diterpene Penitrem (Angew. Chem. Int. Ed. 19/2015). Issue 19 (8th April 2015)

• Record Type: Journal Article
• Authors: Liu, Chengwei; Tagami, Koichi; Minami, Atsushi; Matsumoto, Tomoyuki; Frisvad, Jens Christian; Suzuki, Hideyuki; Ishikawa, Jun; Gomi, Katsuya; Oikawa, Hideaki
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 19(2015)
• Page Start: 5529
• Page End: 5529
• Publication Date: 2015-04-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201502797
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic> <bold>The biosynthetic gene cluster</bold> </italic> of the highly complex indole diterpene penitrem is identified by H. Oikawa et al. in their Communication on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 5748 ff.</ext-link> Thirteen out of the seventeen involved transformations were elucidated by heterologous reconstitution of the relevant genes in Aspergillus oryzae and found to involve a prenylation‐initiated cationic cyclization and two successive P450‐catalyzed oxidative transformations for the installation of the characteristic bicyclo[4.2.0]octane skeleton.<graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjkt6ghbr" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>