A convenient method for palladium‐catalyzed reductive deuteration of organic substrates using deuterated hypophosphite in D2O. (3rd March 2015)

• Record Type: Journal Article
• Authors: Oba, Makoto
• Is Part Of: Journal of labelled compounds & radiopharmaceuticals. Volume 58:Number 5(2015)
• Page Start: 215
• Page End: 219
• Publication Date: 2015-03-03
• Subjects: Tracers (Chemistry) -- Periodicals; Radiopharmaceuticals -- Periodicals; 615.8424
• DOI: 10.1002/jlcr.3277
• Languages: English
• ISSNs: 0362-4803

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A convenient method for the deuteration of organic substrates using deuterated hypophosphite as the deuterium source was investigated. Transfer deuteration of organic substrates, such as aromatic halides, alkenes, alkynes, epoxides, and <italic>O</italic>‐benzyl derivatives, in the presence of palladium on carbon in deuterium oxide proceeded efficiently to give the corresponding deuterated products in excellent yields with high deuterium contents.</p> </abstract>