The relationship between cognitive performance and insulin resistance in non‐diabetic patients with mild cognitive impairment. (25th July 2014)

• Record Type: Journal Article
• Authors: Kim, Tae‐Eun; Lee, Dong Hyun; Kim, Yoon‐Jeong; Mok, Ji Oh; Kim, Chul‐ Hee; Park, Jeong‐Ho; Lee, Tae‐Kyeong; Yoo, Kwangsun; Jeong, Yong; Lee, Yunhwan; Park, Sun Ah
• Is Part Of: International journal of geriatric psychiatry. Volume 30:Number 6(2015:Jun.)
• Page Start: 551
• Page End: 557
• Publication Date: 2014-07-25
• Subjects: Geriatric psychiatry -- Periodicals; Geriatric Psychiatry -- Periodicals; 618.97689
• DOI: 10.1002/gps.4181
• Languages: English
• ISSNs: 0885-6230

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="gps4181-sec-0001" sec-type="section"> <title>Objective</title> <p>Insulin resistance (IR) is a distinct and early feature of type 2 diabetes mellitus and metabolic syndrome. IR is thought to play a vital role in cognitive impairment. We conducted this study to understand the early characteristics of cognitive dysfunctions attributable to IR.</p> </sec> <sec id="gps4181-sec-0002" sec-type="section"> <title>Methods</title> <p>This study included 85 consecutive non‐diabetic elderly participants with mild cognitive impairment (MCI). IR was estimated with the homeostasis model assessment of insulin resistance (HOMA‐IR). Cognitive performances were analyzed as a function of scores on the HOMA‐IR.</p> </sec> <sec id="gps4181-sec-0003" sec-type="section"> <title>Results</title> <p>The group analysis those with and without IR did not show any differences in the cognitive performance although higher HOMA‐IR was closely associated with lower performances in immediate recall on the Seoul Verbal Learning Test (SVLT‐I) (<italic>r</italic> = −0.244, <italic>p</italic> = 0.026) and Controlled Oral Word Association Test (COWAT) (<italic>r</italic> = −0.270, <italic>p</italic> = 0.013). In subgroup analysis by APOE status, SVLT‐delayed (<italic>p</italic> = 0.027) and COWAT (<italic>p</italic> = 0.016) scores were found to be significantly lower in the IR than the non‐IR among those with <italic>APOE</italic> ε4 allele. In multiple regression analysis, impairment on the COWAT remained significantly correlated with scores on HOMA‐IR (<italic>β</italic> = −0.271, <italic>t</italic> = −2.340, <italic>p</italic> = 0.022). However, IR status was identified to interact with <italic>APOE</italic> ε4 carriership toward poor performances in the COWAT (<italic>β</italic> = −0.335, <italic>t</italic> = −2.285, <italic>p</italic> = 0.026).</p> </sec> <sec id="gps4181-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This study found a domain‐specific impact of HOMA‐IR scores on cognitive performances in non‐diabetic patients with MCI. This association was profound only in <italic>APOE</italic> ε4carriers. Copyright © 2014 John Wiley & Sons, Ltd.</p> </sec> </abstract>