COMPUTED TOMOGRAPHIC PNEUMOCOLONOGRAPHY IN NORMAL DOGS. Issue 3 (28th December 2014)

• Record Type: Journal Article
• Authors: Steffey, Michele A.; Daniel, Leticia; Taylor, Sandra L.; Chen, Rachel X.; Zwingenberger, Allison L.
• Is Part Of: Veterinary radiology & ultrasound. Volume 56:Issue 3(2015)
• Page Start: 278
• Page End: 285
• Publication Date: 2014-12-28
• Subjects: Veterinary radiology -- Periodicals; Radiologie vétérinaire -- Périodiques; Échographie vétérinaire -- Périodiques; Radiography -- Periodicals; Ultrasonography -- Periodicals; Diagnosis -- Periodicals; Veterinary Medicine -- Periodicals; Societies, Medical -- Periodicals; 636.089607
• DOI: 10.1111/vru.12235
• Languages: English
• ISSNs: 1058-8183

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Objectives of this prospective study were to describe effects of varying technical components that may contribute to an optimal protocol for computed tomographic pneumocolonography (CTP) in dogs, and to develop a standardized methodology for CTP as a future potential diagnostic tool in canine clinical patients with large bowel disease. Eight purpose‐bred intact male hound cross‐research dogs were enrolled and randomized to groups based on variables of pressure/body position (<italic>n</italic> = 4) and insufflation time (<italic>n</italic> = 4). For each segment of large bowel (rectum, colorectal junction, descending colon, transverse colon, ascending colon), the adequacy of bowel preparation, % of bowel lumen filled with fecal material, and bowel tortuosity or folding were assessed. Measurements of bowel wall thickness (cm), cross‐sectional bowel lumen diameter (cm), and cross‐sectional bowel luminal area (cm<sup>2</sup>) were obtained at standardized locations within the large bowel. False discovery rates (FDR) were calculated to adjust for multiple testing. Values of FDR < 0.05 were considered significant. Differences in mean cross‐sectional area and diameter and bowel wall thickness under increasing pressure were not significant after adjusting for multiple testing; some had raw <italic>p</italic> values <0.05. Ascending colon diameter and ascending colon area significantly increased with insufflation time (FDR < 0.05). No other response variables showed a significant change with insufflation time. The optimal insufflation pressure for maintaining pneumocolon in this study was determined to be 20 mmHg. CTP is a feasible technique to provide consistent distension for imaging of the large bowel and further study on application of CTP in clinical patients is warranted.</p> </abstract>