A growth‐rate composition formula for the growth of E. coli on co‐utilized carbon substrates. Issue 4 (10th April 2015)

• Record Type: Journal Article
• Authors: Hermsen, Rutger; Okano, Hiroyuki; You, Conghui; Werner, Nicole; Hwa, Terence
• Is Part Of: Molecular systems biology. Volume 11:Issue 4(2015:Apr.)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-04-10
• Subjects: Molecular biology -- Periodicals; Systems biology -- Periodicals; 572.8
• DOI: 10.15252/msb.20145537
• Languages: English
• ISSNs: 1744-4292

Abstract

<abstract abstract-type="main" id="msb145537-abs-0001"> <title>Abstract</title> <p>When bacteria are cultured in medium with multiple carbon substrates, they frequently consume these substrates simultaneously. Building on recent advances in the understanding of metabolic coordination exhibited by <italic>Escherichia coli</italic> cells through cAMP‐Crp signaling, we show that this signaling system responds to the total carbon‐uptake flux when substrates are co‐utilized and derive a mathematical formula that accurately predicts the resulting growth rate, based only on the growth rates on individual substrates.</p> </abstract>