A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis. Issue 5 (27th March 2015)

• Record Type: Journal Article
• Authors: Palamiuc, Lavinia; Schlagowski, Anna; Ngo, Shyuan T; Vernay, Aurelia; Dirrig‐Grosch, Sylvie; Henriques, Alexandre; Boutillier, Anne‐Laurence; Zoll, Joffrey; Echaniz‐Laguna, Andoni; Loeffler, Jean‐Philippe; René, Frédérique
• Is Part Of: EMBO molecular medicine. Volume 7:Issue 5(2015:May)
• Page Start: 526
• Page End: 546
• Publication Date: 2015-03-27
• Subjects: Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.15252/emmm.201404433
• Languages: English
• ISSNs: 1757-4676

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="emmm201404433-abs-0003"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Altered metabolic homeostasis is an early event in amyotrophic lateral sclerosis (ALS) manifestation. This study reveals that skeletal muscles stop using glucose as a source of energy but use lipids instead and this chronic pathologic alteration in muscles is exacerbated with disease progression. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjk6vsbfz" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>