Inhibition of lethal inflammatory responses through the targeting of membrane‐associated Toll‐like receptor 4 signaling complexes with a Smad6‐derived peptide. Issue 5 (12th March 2015)

• Record Type: Journal Article
• Authors: Lee, Youn Sook; Park, Jin Seok; Jung, Su Myung; Kim, Sang‐Doo; Kim, Jun Hwan; Lee, Jae Young; Jung, Kyeong Cheon; Mamura, Mizuko; Lee, Sangho; Kim, Seong‐Jin; Bae, Yoe‐Sik; Park, Seok Hee
• Is Part Of: EMBO molecular medicine. Volume 7:Issue 5(2015:May)
• Page Start: 577
• Page End: 592
• Publication Date: 2015-03-12
• Subjects: Molecular biology -- Periodicals; Medical genetics -- Periodicals; Pathology, Molecular -- Periodicals; 616.04205
• DOI: 10.15252/emmm.201404653
• Languages: English
• ISSNs: 1757-4676

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="emmm201404653-abs-0003"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Smaducin‐6, a synthetic membrane‐tethered palmitic acid‐conjugated peptide composed of 20 amino acid of Smad6, is shown here to be the first therapeutic peptide targeting Pellino‐1 in the TLR4 signaling pathway for the treatment of sepsis. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjk6vsbs4" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>