Cu(I)‐Catalyzed Efficient Synthesis of 2′‐Triazolo‐nucleoside Conjugates. (29th May 2014)

• Record Type: Journal Article
• Authors: Mathur, D.; Rana, N.; Olsen, C. E.; Parmar, V. S.; Prasad, A. K.
• Is Part Of: Journal of heterocyclic chemistry. Volume 52:Number 3(2015)
• Page Start: 701
• Page End: 710
• Publication Date: 2014-05-29
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2159
• Languages: English
• ISSNs: 0022-152X

Abstract

<abstract abstract-type="main" id="jhet2159-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p id="jhet2159-para-0002">A small library of thirty‐two 2′‐triazolyl uridine and 2′‐triazolyl‐5‐methyluridine has been synthesized by Cu(I)‐catalyzed condensation of 2′‐azido‐2′‐deoxyuridine and 2′‐azido‐2′‐deoxy‐5‐methyluridine with different alkynes and aryl propargyl ethers in almost quantitative yields. Triazolo‐nucleoside conjugates, which can be evaluated for different <named-content content-type="chemicalTechnology" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">biological activity</named-content> for suitable drug development, were unambiguously identified on the basis of ¹H NMR, ¹³C NMR, IR, and HRMS data analysis. These compounds have been synthesized for the first time and have not been reported in the literature earlier.</p> </abstract>