Autophagy and mitochondrial remodelling in mouse mesenchymal stromal cells challenged with Staphylococcus epidermidis. Issue 5 (26th February 2015)

• Record Type: Journal Article
• Authors: Gorbunov, Nikolai V.; McDaniel, Dennis P.; Zhai, Min; Liao, Pei‐Jyun; Garrison, Bradley R.; Kiang, Juliann G.
• Is Part Of: Journal of cellular and molecular medicine. Volume 19:Issue 5(2015)
• Page Start: 1133
• Page End: 1150
• Publication Date: 2015-02-26
• Subjects: Cytology; Medicine; Molecular Biology; Cytologie -- Périodiques; Médecine -- Périodiques; Biologie moléculaire -- Périodiques; Cytology -- Periodicals; Medicine -- Periodicals; Molecular biology -- Periodicals; 611.01805
• DOI: 10.1111/jcmm.12518
• Languages: English
• ISSNs: 1582-1838

Abstract

<abstract abstract-type="main" id="jcmm12518-abs-0001"> <title>Abstract</title> <p>The bone marrow stroma constitutes the marrow‐blood barrier, which sustains immunochemical homoeostasis and protection of the haematopoietic tissue in sequelae of systemic bacterial infections. Under these conditions, the bone marrow stromal cells affected by circulating bacterial pathogens shall elicit the adaptive stress‐response mechanisms to maintain integrity of the barrier. The objective of this communication was to demonstrate (<italic>i</italic>) that <italic>in vitro</italic> challenge of mesenchymal stromal cells, <italic>i.e</italic>. colony‐forming unit fibroblasts (CFU‐F), with <italic>Staphylococcus epidermidis</italic> can activate the autophagy pathway to execute antibacterial defence response, and (<italic>ii</italic>) that homoeostatic shift because of the bacteria‐induced stress includes the mitochondrial remodelling and sequestration of compromised organelles <italic>via</italic> mitophagy. Implication of Drp1 and PINK1–PARK2‐dependent mechanisms in the mitophagy turnover of the aberrant mitochondria in mesenchymal stromal cells is investigated and discussed.</p> </abstract>