Endothelial progenitor cell biology in ankylosing spondylitis. (28th October 2014)

• Record Type: Journal Article
• Authors: Verma, Inderjeet; Syngle, Ashit; Krishan, Pawan
• Is Part Of: International journal of rheumatic diseases. Volume 18:Number 3(2015)
• Page Start: 336
• Page End: 340
• Publication Date: 2014-10-28
• Subjects: Rheumatology -- Periodicals; Rheumatology -- Asia -- Periodicals; Rheumatology -- Pacific Area -- Periodicals; Rheumatic Diseases -- Periodicals; Connective Tissue Diseases -- Periodicals; Immune System Diseases -- Periodicals; 616.723
• DOI: 10.1111/1756-185X.12487
• Languages: English
• ISSNs: 1756-1841

Abstract

<abstract abstract-type="main" id="apl12487-abs-0001"> <title>Abstract</title> <sec id="apl12487-sec-0001" sec-type="section"> <title>Aim</title> <p>Endothelial progenitor cells (EPCs) are unique populations which have reparative potential in overcoming endothelial damage and reducing cardiovascular risk. Patients with ankylosing spondylitis (AS) have increased risk of cardiovascular morbidity and mortality. The aim of this study was to investigate the endothelial progenitor cell population in AS patients and its potential relationships with disease variables.</p> </sec> <sec id="apl12487-sec-0002" sec-type="section"> <title>Methods</title> <p>Endothelial progenitor cells were measured in peripheral blood samples from 20 AS and 20 healthy controls by flow cytometry on the basis of CD34 and CD133 expression. Disease activity was evaluated by using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Functional ability was monitored by using Bath Ankylosing Spondylitis Functional Index (BASFI).</p> </sec> <sec id="apl12487-sec-0003" sec-type="section"> <title>Results</title> <p>EPCs were depleted in AS patients as compared to healthy controls (CD34<sup>+</sup>/CD133<sup>+</sup>: 0.027 ± 0.010% <italic>vs</italic>. 0.044 ± 0.011%, <italic>P </italic><<italic> </italic>0.001). EPC depletions were significantly associated with disease duration (<italic>r </italic>= −0.52, <italic>P </italic>=<italic> </italic>0.01), BASDAI (<italic>r </italic>= −0.45, <italic>P </italic>=<italic> </italic>0.04) and C‐reactive protein (<italic>r </italic>= −0.5, <italic>P </italic>=<italic> </italic>0.01).</p> </sec> <sec id="apl12487-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This is the first study to demonstrate endothelial progenitor cell depletion in AS patients. EPC depletions inversely correlate with disease duration, disease activity and inflammation, suggesting the pivotal role of inflammation in depletion of EPCs. EPC would possibly also serve as a therapeutic target for preventing cardiovascular disease in AS.</p> </sec> </abstract>