Adjuvant activity of fish type I interferon shown in a virus DNA vaccination model. Issue 21 (15th May 2015)

• Record Type: Journal Article
• Authors: Chang, Chia-Jung; Sun, Baojian; Robertsen, Børre
• Is Part Of: Vaccine. Volume 33:Issue 21(2015)
• Page Start: 2442
• Page End: 2448
• Publication Date: 2015-05-15
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.03.093
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Co-injection of IFN plasmid and hemagglutininesterase plasmid in salmon strongly enhanced protection against ISA virus.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">IFN plasmids increased antibody response induced by the ISA virus DNA vaccine.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">IFNa, IFNb and IFNc plasmids showed similar adjuvant effects.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Recombinant IFNc enhanced the antibody response to inactivated virus.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">qPCR showed that IFN plasmids cause increased influx of B and CD8 T cells.</p> </list-item> </list> </p> </sec> </abstract>