Sequence analysis and characterisation of virally induced viperin in the saltwater crocodile (Crocodylus porosus). Issue 1 (July 2015)

• Record Type: Journal Article
• Authors: Milic, Natalie L.; Davis, Steven; Carr, Jillian M.; Isberg, Sally; Beard, Michael R.; Helbig, Karla J.
• Is Part Of: Developmental and comparative immunology. Volume 51:Issue 1(2015)
• Page Start: 108
• Page End: 115
• Publication Date: 2015-07
• Subjects: Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2015.03.001
• Languages: English
• ISSNs: 0145-305X

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010"> <italic>C. porosus</italic> viperin is the shortest viperin species cloned to date at 338 amino acids.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015"> <italic>C. porosus</italic> viperin localises to lipid droplets, most likely via its N-terminal amphipathic helix.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020"> <italic>C. porosus</italic> cells maintain the ability to respond to both dsRNA, dsDNA and infectious ssRNA +ve and –ve sense viruses.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Dengue viral infection of mammalian cells is significantly restricted by <italic>C. porosus</italic> viperin.</p> </list-item> </list> </p> </sec> </abstract>