A defensin from clam Venerupis philippinarum: Molecular characterization, localization, antibacterial activity, and mechanism of action. Issue 1 (July 2015)

• Record Type: Journal Article
• Authors: Zhang, Linbao; Yang, Dinglong; Wang, Qing; Yuan, Zeyi; Wu, Huifeng; Pei, Dong; Cong, Ming; Li, Fei; Ji, Chenglong; Zhao, Jianmin
• Is Part Of: Developmental and comparative immunology. Volume 51:Issue 1(2015)
• Page Start: 29
• Page End: 38
• Publication Date: 2015-07
• Subjects: Immunology -- Periodicals; Developmental immunology -- Periodicals; 616.079
• DOI: 10.1016/j.dci.2015.02.009
• Languages: English
• ISSNs: 0145-305X

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">We cloned a gene of an invertebrate defensin from the clam <italic>V. philippinarum.</italic></p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">VpDef was constitutively expressed in hemocytes and mantles of the clam.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020"> <italic>VpDef</italic> transcripts were significantly induced after <italic>Vibrio anguillarum</italic> infection.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">rVpDef showed the highest activity against <italic>Micrococcus luteus</italic>.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">VpDef appears to kill microbes by inducing membrane lesions.</p> </list-item> </list> </p> </sec> </abstract>