Clinical outcome of deep brain stimulation for dystonia: constant‐current or constant‐voltage stimulation? A non‐randomized study. (10th July 2014)

• Record Type: Journal Article
• Authors: Lettieri, C.; Rinaldo, S.; Devigili, G.; Pisa, F.; Mucchiut, M.; Belgrado, E.; Mondani, M.; D'Auria, S.; Ius, T.; Skrap, M.; Eleopra, R.
• Is Part Of: European journal of neurology. Volume 22:Number 6(2015:Jun.)
• Page Start: 919
• Page End: 926
• Publication Date: 2014-07-10
• Subjects: Neurology -- Periodicals; Nervous system -- Diseases -- Periodicals; 616.8
• DOI: 10.1111/ene.12515
• Languages: English
• ISSNs: 1351-5101

Abstract

<abstract abstract-type="main" id="ene12515-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ene12515-sec-0001" sec-type="section"> <title>Background and purpose</title> <p>Bilateral globus pallidus deep brain stimulation (GPi‐DBS) represents an effective and relatively safe therapy for different forms of refractory dystonia. The aim of this study was to assess, retrospectively, the effect of two different stimulation settings during GPi‐DBS in 22 patients affected by primary generalized or multi‐segmental dystonia.</p> </sec> <sec id="ene12515-sec-0002" sec-type="section"> <title>Methods</title> <p>Thirteen patients were stimulated using a voltage‐controlled setting whilst in the other nine patients a current‐controlled setting was used. Clinical features were evaluated for each patient at baseline, 6 months and 12 months after surgery by means of the Burke−Fahn−Marsden Dystonia Rating Scale.</p> </sec> <sec id="ene12515-sec-0003" sec-type="section"> <title>Results</title> <p>Globus pallidus deep brain stimulation was effective in all patients. However, comparing constant‐current and constant‐voltage stimulation, a better outcome was found in the current‐controlled group during the last 6 months of follow‐up.</p> </sec> <sec id="ene12515-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Current‐controlled stimulation is effective during GPi‐DBS for primary dystonia and it could be a better choice than voltage‐controlled stimulation over long‐term follow‐up.</p> </sec> </abstract>