Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome‐Wide Association Study. Issue 5 (May 2015)

• Record Type: Journal Article
• Authors: Renauer, Paul A.; Saruhan‐Direskeneli, Guher; Coit, Patrick; Adler, Adam; Aksu, Kenan; Keser, Gokhan; Alibaz‐Oner, Fatma; Aydin, Sibel Z.; Kamali, Sevil; Inanc, Murat; Carette, Simon; Cuthbertson, David; Hoffman, Gary S.; Akar, Servet; Onen, Fatos; Akkoc, Nurullah; Khalidi, Nader A.; Koening, Curry; Karadag, Omer; Kiraz, Sedat; Langford, Carol A.; Maksimowicz‐McKinnon, Kathleen; McAlear, Carol A.; Ozbalkan, Zeynep; Ates, Askin; Karaaslan, Yasar; Duzgun, Nursen; Monach, Paul A.; Ozer, Huseyin T. E.; Erken, Eren; Ozturk, Mehmet A.; Yazici, Ayten; Cefle, Ayse; Onat, Ahmet Mesut; Kisacik, Bunyamin; Pagnoux, Christian; Kasifoglu, Timucin; Seyahi, Emire; Fresko, Izzet; Seo, Philip; Sreih, Antoine G.; Warrington, Kenneth J.; Ytterberg, Steven R.; Cobankara, Veli; Cunninghame‐Graham, Deborah S.; Vyse, Timothy J.; Pamuk, Omer N.; Tunc, S. Ercan; Dalkilic, Ediz; Bicakcigil, Muge; Yentur, Sibel P.; Wren, Jonathan D.; Merkel, Peter A.; Direskeneli, Haner; Sawalha, Amr H.;
• Is Part Of: Arthritis & rheumatology. Volume 67:Issue 5(2015)
• Page Start: 1361
• Page End: 1368
• Publication Date: 2015-05
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/art.39035
• Languages: English
• ISSNs: 2326-5191

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="art39035-sec-0001" sec-type="section"> <title>Objective</title> <p>Takayasu arteritis is a rare large vessel vasculitis with incompletely understood etiology. This study was undertaken to perform the first unbiased genome‐wide association analysis of Takayasu arteritis.</p> </sec> <sec id="art39035-sec-0002" sec-type="section"> <title>Methods</title> <p>Two independent cohorts of patients with Takayasu arteritis from Turkey and North America were included in our study. The Turkish cohort consisted of 559 patients and 489 controls, and the North American cohort consisted of 134 patients and 1, 047 controls of European ancestry. Genotyping was performed using the Omni1‐Quad and Omni2.5 genotyping arrays. Genotyping data were subjected to rigorous quality control measures and subsequently analyzed to discover genetic susceptibility loci for Takayasu arteritis.</p> </sec> <sec id="art39035-sec-0003" sec-type="section"> <title>Results</title> <p>We identified genetic susceptibility loci for Takayasu arteritis with a genome‐wide level of significance in <italic>IL6</italic> (rs2069837) (odds ratio [OR] 2.07, <italic>P</italic> = 6.70 × 10<sup>−9</sup>), <italic>RPS9</italic>/<italic>LILRB3</italic> (rs11666543) (OR 1.65, <italic>P</italic> = 2.34 × 10<sup>−8</sup>), and an intergenic locus on chromosome 21q22 (rs2836878) (OR 1.79, <italic>P</italic> = 3.62 × 10<sup>−10</sup>). The genetic susceptibility locus in <italic>RPS9</italic>/<italic>LILRB3</italic> lies within the leukocyte receptor complex gene cluster on chromosome 19q13.4, and the disease risk variant in this locus correlates with reduced expression of multiple genes including the inhibitory leukocyte immunoglobulin‐like receptor gene <italic>LILRB3</italic> (<italic>P</italic> = 2.29 × 10<sup>−8</sup>). In addition, we identified candidate susceptibility genes with suggestive levels of association (<italic>P</italic> < 1 × 10<sup>−5</sup>) with Takayasu arteritis, including <italic>PCSK5, LILRA3, PPM1G/NRBP1</italic>, and <italic>PTK2B</italic>.</p> </sec> <sec id="art39035-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Our findings indicate novel genetic susceptibility loci for Takayasu arteritis and uncover potentially important aspects of the pathophysiology of this form of vasculitis.</p> </sec> </abstract>