Calcium channel blocker attenuated opioid withdrawal syndrome. Issue 2 (8th August 2014)

• Record Type: Journal Article
• Authors: Shimatani, Tatsutoshi; Adachi, Hiroshi; Mihashi, Hiroyuki; Usumoto, Noriko; Yoshimoto, Kohei; Ayukawa, Katsuhiko
• Is Part Of: Acute medicine & surgery. Volume 2:Issue 2 (2015)
• Page Start: 114
• Page End: 116
• Publication Date: 2014-08-08
• Subjects: Surgery -- Periodicals; Medical emergencies -- Periodicals; 617.005
• DOI: 10.1002/ams2.72
• Languages: English
• ISSNs: 2052-8817

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ams272-sec-0001" sec-type="section"> <title>Case</title> <p>A 61‐year‐old woman was diagnosed with deep cervical abscess and enlarged mediastinal abscess. These required a protracted period of mechanical ventilation and neck and thoracic drainage surgery with daily wound lavage, necessitating the administration of large amounts of fentanyl and dexmedetomidine. After extubation, fentanyl was discontinued but dexmedetomidine was continued, and she developed hypertension, tachycardia, tachypnea, and hyperthermia within several hours; therefore, she was diagnosed with opioid withdrawal syndrome. Her symptoms failed to improve with either an increased dexmedetomidine dose or a diltiazem infusion for symptomatic management. Ultimately, 20 mg nifedipine was given through a nasogastric tube, which led to a resolution of withdrawal symptoms.</p> </sec> <sec id="ams272-sec-0002" sec-type="section"> <title>Outcome</title> <p>This is the first case of calcium channel blockers attenuating opioid withdrawal syndrome symptoms in a human.</p> </sec> <sec id="ams272-sec-0003" sec-type="section"> <title>Conclusion</title> <p>Calcium channel blockers might be alternative therapy to refractory opioid withdrawal syndrome. Case accumulation in the future is expected.</p> </sec> </abstract>