Challenges regarding analysis of unbound fraction of highly bound protein antiretroviral drugs in several biological matrices: lack of harmonisation and guidelines. Issue 4 (April 2015)

• Record Type: Journal Article
• Authors: Illamola, Sílvia M.; Hirt, Déborah; Tréluyer, Jean M.; Urien, Saik; Benaboud, Sihem
• Is Part Of: Drug discovery today. Volume 20:Issue 4(2015)
• Page Start: 466
• Page End: 474
• Publication Date: 2015-04
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2014.11.010
• Languages: English
• ISSNs: 1359-6446

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Critical revision of methods used to quantitate unbound concentrations of ARV drugs.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">There is a lack of validation guidelines for these methods.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Some of the published studies have been partially validated.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Binding studies can be of great utility in many research and clinical situations.</p> </list-item> </list> </p> </sec> </abstract>