In vitro cadmium effects on ECM gene expression in human bronchial epithelial cells. Issue 1 (March 2015)

• Record Type: Journal Article
• Authors: Baroni, Tiziano; Lilli, Cinzia; Bellucci, Catia; Luca, Giovanni; Mancuso, Francesca; Fallarino, Francesca; Falabella, Giulia; Arato, Iva; Calvitti, Mario; Marinucci, Lorella; Muzi, Giacomo; Dell'Omo, Marco; Gambelunghe, Angela; Bodo, Maria
• Is Part Of: Cytokine. Volume 72:Issue 1(2015)
• Page Start: 9
• Page End: 16
• Publication Date: 2015-03
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2014.12.002
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st085">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0140">We exposed human BEAS-2B cells <italic>in vitro</italic> to sub-toxic and toxic concentrations of Cd.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0145">Sub-toxic Cd dose increased tenascin, vitronectin, β1 and β5 integrin gene expression.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0150">The toxic Cd dose decreased type IV and V collagen, α1, α2 and β3 integrins.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0155">Each Cd dose caused a different imbalance in the pattern of TGFβ/TGFβR.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0160">Cd-induced lung disease may involve downstream changes in TGFβ/TGFβR signaling.</p> </list-item> </list> </p> </sec> </abstract>