Genetic variation in the promoter region of pro-inflammatory cytokine TNF-α in perinatal HIV transmission from Mumbai, India. Issue 1 (March 2015)

• Record Type: Journal Article
• Authors: Ahir, Swati; Mania-Pramanik, Jayanti; Chavan, Vijay; Kerkar, Shilpa; Samant-Mavani, Padmaja; Nanavati, Ruchi; Mehta, Preeti
• Is Part Of: Cytokine. Volume 72:Issue 1(2015)
• Page Start: 25
• Page End: 30
• Publication Date: 2015-03
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2014.11.022
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st090">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0140">The study reports association of <italic>TNF</italic> (rs1800629) with vertical HIV transmission.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0145">GG at <italic>TNF</italic> (rs1800629) acted as protective whereas GA a susceptible factor.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0150">The 'G' allele frequency was significantly higher in negative children.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0155">Haplotypes of <italic>TNF</italic> (-308:-238) also contribute to HIV transmission in children.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0160">Genotypic variants of <italic>TNF</italic> (rs1800629) may predict vertical HIV transmission.</p> </list-item> </list> </p> </sec> </abstract>