Oncostatin M binds to extracellular matrix in a bioactive conformation: Implications for inflammation and metastasis. Issue 1 (March 2015)

• Record Type: Journal Article
• Authors: Ryan, Randall E.; Martin, Bryan; Mellor, Liliana; Jacob, Reed B.; Tawara, Ken; McDougal, Owen M.; Oxford, Julia Thom; Jorcyk, Cheryl L.
• Is Part Of: Cytokine. Volume 72:Issue 1(2015)
• Page Start: 71
• Page End: 85
• Publication Date: 2015-03
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2014.11.007
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="graphical" id="ab005"> <title> <x xml:space="preserve">Abstract</x> </title> <fig id="f0065" position="anchor"> <graphic position="anchor" xlink:href="ark:/27927/pgh3t33bd1m" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </fig> <sec> <title id="st125">Graphical abstract</title> <p id="sp0005"> <bold>Model for OSM role in chronic inflammation and tumor metastasis.</bold> Inflammatory cells infiltrate into a particular microenvironment and secrete OSM, which binds to ECM and helps to nurture an inflammatory microenvironment. Immobilized bioactive OSM will help to maintain a prolonged OSM response ultimately resulting in chronic inflammation. A non-OSM secreting, proliferating tumor may also come into contact with immobilized OSM secreted from inflammatory cells. The interaction of immobilized OSM with proliferating tumor cells may induce an EMT in the tumor cells and enhance tumor metastasis.</p> </sec> </abstract>