Evaluation of the toxicity data for peracetic acid in deriving occupational exposure limits: A minireview. Issue 1 (17th February 2015)

• Record Type: Journal Article
• Authors: Pechacek, Nathan; Osorio, Magdalena; Caudill, Jeff; Peterson, Bridget
• Is Part Of: Toxicology letters. Volume 233:Issue 1(2015)
• Page Start: 45
• Page End: 57
• Publication Date: 2015-02-17
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2014.12.014
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0040"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">A mini-review of the toxicity data for peracetic acid (PAA) was conducted in the context of deriving health-based occupational exposure limits (OEL).</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The available toxicity data for PAA frequently suffer from deficiencies in reporting, information gaps and unconventional testing methodology</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">In spite of these limitations, sensory irritation is identified as the most sensitive health endpoint and serves as the point-of-departure upon which health-based OELs are derived.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Time-weighted average (TWA) OELs are derived and range from 0.36 to 0.51 mg/m³ (0.1–0.2 ppm). Short-term exposure limit (STEL) OELs also are derived and range from 1.2 to 1.7 mg/m³ (0.4–0.5 ppm).</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">A joint TWA/STEL approach is recommended to effectively mitigate PAA workplace inhalation hazards with selection of specific OELs within the proposed ranges being a risk management decision.</p> </list-item> </list> </p> </sec> </abstract>