Extreme Values of Hemoglobin A1c Are Associated With Increased Risks of Chronic Obstructive Pulmonary Disease in Patients With Type 2 Diabetes. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Li, Chia-Ing; Li, Tsai-Chung; Liu, Chiu-Shong; Lin, Wen-Yuan; Chen, Ching-Chu; Yang, Sing-Yu; Lin, Cheng-Chieh; Shao., Jiaqing
• Is Part Of: Medicine. Volume 94:Issue 1(2015)
• Publication Date: 2015-01
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Geneeskunde; Medicine; Periodicals; Periodicals; 610.5
• DOI: 10.1097/MD.0000000000000367
• Languages: English
• ISSNs: 0025-7974

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>The purpose of this study was to evaluate the relationship between glycated hemoglobin (HbA1c) and chronic obstructive pulmonary disease (COPD) in patients with type 2 diabetes.</p> <p>We conducted a retrospective cohort study involving 45, 753 patients with type 2 diabetes, who participated in the National Diabetes Case Management Program in Taiwan. HbA1c at baseline and COPD events over the subsequent years were analyzed.</p> <p>After multivariate adjustment, the COPD risk increased among patients with HbA1c levels &lt;6.0%, compared with that in patients with HbA1c levels ranging from 6.0% to 7.0% (hazard ratio: 1.19, 95% confidence interval (CI): 1.06–1.34). Similarly, high HbA1c levels (≥10%) were independently associated with COPD (1.19, 95% CI: 1.06–1.32). A U-shaped relationship was observed between HbA1c levels and COPD incidence.</p> <p>HbA1c levels lower than 6.0% and higher than 10% are associated with an increased risk of COPD in patients with type 2 diabetes. These findings suggest that meeting the recommended HbA1c targets might reduce the risk of COPD, but care should be taken not to pose risks to this population.</p> </sec> </abstract>