Volumetric comparison of positron emission tomography/computed tomography using 4′-[methyl-11C]-thiothymidine with 2-deoxy-2-18F-fluoro-D-glucose in patients with advanced head and neck squamous cell carcinoma. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Ito, Kimiteru; Yokoyama, Junkichi; Miyata, Yoko; Toyohara, Jun; Okasaki, Momoko; Minamimoto, Ryogo; Morooka, Miyako; Ishiwata, Kiichi; Kubota, Kazuo
• Is Part Of: Nuclear medicine communications. Volume 36:Issue 3(2015:Mar.)
• Publication Date: 2015-03
• Subjects: Nuclear medicine -- Periodicals; 616.07575
• DOI: 10.1097/MNM.0000000000000241
• Languages: English
• ISSNs: 0143-3636

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective</title> <p>We prospectively compared the diagnostic value of PET/computed tomography (CT) findings using the tracers 4′-[methyl-<sup>11</sup>C]-thiothymidine (<sup>11</sup>C-4DST) and 2-deoxy-2-<sup>18</sup>F-fluoro-D-glucose (<sup>18</sup>F-FDG) in patients with head and neck squamous cell carcinoma (HNSCC).</p> </sec> <sec> <title>Patients and methods</title> <p>Thirty-eight patients with advanced HNSCC underwent <sup>11</sup>C-4DST PET/CT and <sup>18</sup>F-FDG PET/CT before treatment. Maximum standardized uptake values (SUV<sub>max</sub>) were measured for both PET/CT studies; in addition, total lesion glycolysis (TLG) of <sup>18</sup>F-FDG PET/CT and total lesion proliferation (TLP) of <sup>11</sup>C-4DST PET/CT were measured. Absolute TLG and TLP values as well as values with various SUV thresholds were measured. All patients were followed up for 13.5±7.5 months (mean±SD) to monitor recurrence.</p> </sec> <sec> <title>Results</title> <p>A statistically significant correlation was observed between the primary tumor SUV<sub>max</sub> for <sup>11</sup>C-4DST PET/CT and <sup>18</sup>F-FDG PET/CT (<italic>r</italic>=0.46, <italic>P</italic><0.01). TLP values with SUV thresholds strongly correlated with TLG values relative to the same thresholds (<italic>r</italic>=0.60–0.92, <italic>P</italic><0.001). Nine of the 38 patients with post-treatment recurrence were identified. Receiver operating characteristic curves for TLG<sub>3.0</sub> and TLP<sub>2.5</sub> showed the highest prognostic ability for recurrence; the sensitivity and specificity of TLG<sub>3.0</sub> were 89 and 72%, respectively, and the sensitivity and specificity of TLP<sub>2.5</sub> were 89 and 55%, respectively.</p> </sec> <sec> <title>Conclusion</title> <p>In patients with advanced HNSCC, the TLP of <sup>11</sup>C-4DST PET/CT strongly correlated with the TLG of <sup>18</sup>F-FDG PET/CT. Although there were no large differences between these values, the receiver operating characteristic curves of the absolute TLG had slightly better prognostic ability for recurrence.</p> </sec> </abstract>