Comparison of Quantitative and Semiquantitative Dynamic Contrast-Enhanced MRI With Respect to Their Correlation to Delayed Gadolinium-Enhanced MRI of the Cartilage in Patients With Early Rheumatoid Arthritis. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Müller-Lutz, Anja; Schleich, Christoph; Sewerin, Philipp; Groß, Janina; Pentang, Gael; Wittsack, Hans-Jörg; Antoch, Gerald; Schneider, Matthias; Ostendorf, Benedikt; Miese, Falk
• Is Part Of: Journal of computer assisted tomography. Volume 39:Issue 1(2015)
• Publication Date: 2015-01
• Subjects: Tomography -- Periodicals; Tomography -- Periodicals; Tomography; Periodicals; 616.0757
• DOI: 10.1097/RCT.0000000000000164
• Languages: English
• ISSNs: 0363-8715

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective</title> <p>The objective of this study was to investigate the correlation between semiquantitative and quantitative dynamic contrast-enhanced (DCE) parameters with delayed gadolinium-enhanced magnetic resonance imaging (MRI) of the cartilage (dGEMRIC).</p> </sec> <sec> <title>Methods</title> <p>Fifteen patients with early rheumatoid arthritis (RA) from the ArthroMark cohort were investigated at a 3-T MRI scanner. The metacarpophalangeal (MCP) joint of the index finger was examined with DCE-MRI and dGEMRIC. Semiquantitative and quantitative DCE perfusion parameters were calculated. The RA MRI score of the second MCP joint and the joint space width were measured.</p> </sec> <sec> <title>Results</title> <p>Significant correlations were noted between both semiquantitative and quantitative DCE parameters and the RA MRI score of the second MCP joint. There was a significant negative correlation between DCE parameters and dGEMRIC. No association between joint space width and DCE parameters was observed.</p> </sec> <sec> <title>Conclusions</title> <p>Semiquantitative and quantitative analyses of perfusion are applicable to show that cartilage damage correlates with the inflammation activity despite the absence of joint space narrowing.</p> </sec> </abstract>