Methyl-CpG binding domain 4 tagging polymorphisms and esophageal cancer risk in a Chinese population. Issue 2 (March 2015)

• Record Type: Journal Article
• Authors: Yin, Jun; Shi, Yijun; Zuo, Junbo; Tang, Weifeng; Wang, Liming; Wang, Xu; Shao, Aizhong; Ding, Guowen; Liu, Chao; Liu, Ruiping; Chen, Suocheng; Gu, Haiyong; Zheng, Liang
• Is Part Of: European journal of cancer prevention. Volume 24:Issue 2(2015:Mar.)
• Publication Date: 2015-03
• Subjects: Cancer -- Prevention -- Periodicals; Neoplasms -- etiology -- Periodicals; Neoplasms -- prevention & control -- Periodicals; Cancer -- Prevention; Periodicals; 616.994052
• DOI: 10.1097/CEJ.0000000000000081
• Languages: English
• ISSNs: 0959-8278

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <p>In 2009, esophageal cancer was recorded as the fifth most commonly diagnosed cancer and the fourth leading cause of cancer-related death in China. Esophageal squamous cell carcinoma (ESCC) accounts for more than 90% of esophageal cancers. Genetic factors might play an important role in the carcinogenesis of ESCC. We conducted a hospital-based case–control study to evaluate the association between methyl-CpG binding domain 4 (<italic>MBD4</italic>) rs3138373 A>G, rs2005618 T>C, and rs3138355 G>A tag single nucleotide polymorphisms and the risk of developing ESCC. A total of 629 ESCC patients and 686 controls were recruited. Genotypes were determined using the ligation detection reaction method. When the <italic>MBD4</italic> rs3138355 GG homozygous genotype was used as the reference group, the GA, AA, and GA/AA genotypes were not associated with ESCC risk. In the recessive model, when the <italic>MBD4</italic> rs3138355 GG/GA genotypes were used as the reference group, the AA homozygous genotype was associated with a 28% decreased risk for ESCC (AA vs. GG/GA: adjusted odds ratio=0.72, 95% confidence interval=0.53–0.99, <italic>P</italic>=0.040). The <italic>MBD4</italic> rs3138373 A>G and rs2005618 T>C single nucleotide polymorphisms were not associated with ESCC risk. The <italic>MBD4</italic> rs3138355 G>A polymorphism was associated with a significantly decreased risk of ESCC among male and older patients. The <italic>MBD4</italic> rs3138355 GG genotype was associated with a decreased risk of ESCC among male patients and the elderly. Additional, larger studies are required to confirm these current findings.</p> </sec> </abstract>