Do 18F-FDG PET/CT Parameters in Oropharyngeal and Oral Cavity Squamous Cell Carcinomas Indicate HPV Status?. (March 2015)

• Record Type: Journal Article
• Authors: Kendi, Ayse Tuba Karagulle; Magliocca, Kelly; Corey, Amanda; Nickleach, Dana C.; Galt, James; Higgins, Kristin; Beitler, Jonathan J.; El-Deiry, Mark W.; Wadsworth, J. Trad; Hudgins, Patricia A.; Saba, Nabil F.; Schuster, David M.
• Is Part Of: Clinical nuclear medicine. Volume 40:Number 3(2015)
• Publication Date: 2015-03
• Subjects: Nuclear medicine -- Periodicals; Radioisotope scanning -- Periodicals; Nuclear Medicine -- Periodicals; 616.07575
• DOI: 10.1097/RLU.0000000000000691
• Languages: English
• ISSNs: 0363-9762

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Objective</title> <p>The aim of this study was to explore the relationship of PET/CT parameters with human papillomavirus (HPV) status of oropharyngeal (OP) and oral cavity (OC) squamous cell carcinomas (SCCs).</p> </sec> <sec> <title>Patients and Methods</title> <p>We retrospectively reviewed 39 patients with OC and OP-SCC who underwent staging <sup>18</sup>F-FDG PET/CT. PET/CT parameters were measured for the primary tumor and the hottest involved node, including SUV<sub>max</sub>, SUV<sub>mean</sub>, SUV<sub>peak</sub>, metabolic tumor volume, total lesion glycolysis, standardized added metabolic activity (SAM), and normalized SAM. Patient characteristics were compared between HPV positive (HPV+) and negative (HPV−) groups. Receiver operating characteristic analysis was used to dichotomize PET/CT parameters into high and low. Logistic regression models predicting HPV status were fit for each PET/CT parameter.</p> </sec> <sec> <title>Results</title> <p>The HPV+ group was composed of 18 patients all with OP-SCC; the HPV− group consisted of 21 patients, 4 OP cancer patients and 17 OC cancer patients. The HPV+ group had a higher proportion of N2 stage (94% vs 43%; <italic>P</italic> < 0.001). Nodal PET/CT parameters were higher in the HPV+ group (<italic>P</italic> < 0.01); this difference was not present for the primary lesion. After adjusting for sex and age, the association of higher nodal SUV<sub>max</sub> (odds ratio [OR], 9.67), SUV<sub>mean</sub> (OR, 10.48), SUV<sub>peak</sub> (OR 9.67), metabolic tumor volume (OR, 14.52), total lesion glycolysis (OR, 11.84), and SAM, normalized SAM (OR, 16.21) with HPV+ status remained statistically significant (<italic>P</italic> < 0.05).</p> </sec> <sec> <title>Conclusions</title> <p>Nodal PET/CT parameters predict HPV status. High nodal FDG uptake should raise suspicion for positive HPV status in the evaluation of the primary lesion.</p> </sec> </abstract>