Is Sentinel Node Susceptibility to Metastases Related to Nodal Immune Modulation?. Issue 1 (January 2015)

• Record Type: Journal Article
• Authors: Cochran, Alistair J.; Huang, Rong-Rong; Su, Albert; Itakura, Eijun; Wen, Duan-Ren
• Is Part Of: Cancer journal. Volume 21:Issue 1(2015)
• Publication Date: 2015-01
• Subjects: Cancer -- Periodicals; 616.994005
• DOI: 10.1097/PPO.0000000000000094
• Languages: English
• ISSNs: 1528-9117

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <sec> <title>Abstract</title> <p>Sentinel lymph nodes (SLNs), the initial site of regional metastases, directly receive lymph containing immune-modulatory cytokines and tumor cells from primary melanomas. Immune-suppressed SLNs are ideal for studies of tissue susceptibility to metastases. They show reduced antigen-presenting dendritic cells, activated T cells, high endothelial venules, and transvenular immigration of T cells. Tumor-induced immune suppression contributes to establishment of nodal metastases. SLNs may serve as an effective model to study reversal of tumor-induced immune suppression. We reviewed this topic in <italic>Nature Reviews of Immunology</italic> in 2006. We here summarize the <italic>Nature</italic> paper and provide additional results from ongoing studies and the recent literature.</p> </sec> </abstract>