Clinical outcome of deep-seated atypical lipomatous tumor of the extremities with median-term follow-up study. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Kito, M.; Yoshimura, Y.; Isobe, K.; Aoki, K.; Momose, T.; Suzuki, S.; Tanaka, A.; Sano, K.; Akahane, T.; Kato, H.
• Is Part Of: European journal of surgical oncology. Volume 41:Issue 3(2015:Mar.)
• Page Start: 400
• Page End: 406
• Publication Date: 2015-03
• Subjects: Oncology -- Periodicals; Cancer -- Surgery -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- surgery -- Periodicals; Cancer -- Chirurgie -- Périodiques; Cancérologie -- Périodiques; Oncologie; Chirurgie (geneeskunde); Electronic journals; Electronic journals -- Sciences; Electronic journals -- Medicine; Electronic journals; 616.994059005
• DOI: 10.1016/j.ejso.2014.11.044
• Languages: English
• ISSNs: 0748-7983

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Aims</title> <p id="abspara0010">There is no consensus on the best surgical treatment for deep-seated atypical lipomatous tumor (ALT) of the extremities; furthermore, the appropriate duration for follow-up observation remains unclear. We investigated clinical and functional median-term outcomes in the primary operations for ALT of the extremities in order to find its best treatment methods and observation periods.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">From 1996 to 2009, we diagnosed 41 patients with deep-seated ALT of the extremities. Wide resection was performed on 11 patients and marginal resection was performed on 30 patients. The minimum follow-up was 5 years (median, 8.5; range, 5–17.4). Patients were evaluated for their local recurrence, dedifferentiation, and post-operative function using the ISOLS/MSTS scoring system.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">Recurrence and dedifferentiation rates were both 0% for the wide resection group, while the rates were 23% (7/30) and 3% (1/30) for the marginal resection group, respectively. Median duration before recurrence was 7.2 years (range, 4.0–14.2). Local recurrence-free survival rate was significantly higher in the wide resection group (<italic>P</italic> = 0.013). In the marginal resection group, 10% (3/30) of the cases showed residual tumor. The localization of these tumors was all intermuscular. The ISOLS/MSTS scores were 98% (range, 90–100) for wide resection and 99% (range, 93–100) for marginal resection, with no statistical difference (<italic>P</italic> = 0.694). No ALT-related deaths occurred during the observation period.</p> </sec> <sec> <title id="sectitle0030">Conclusions</title> <p id="abspara0025">In addition to long-term (at least 8 years) of continuous observation, a wide resection is necessary in order to prevent recurrence, dedifferentiation, and residual tumor.</p> </sec> </abstract>