NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth. Issue 1 (1st April 2015)

• Record Type: Journal Article
• Authors: Zha, Xiaojun; Hu, Zhongdong; Ji, Shuang; Jin, Fuquan; Jiang, Keguo; Li, Chunjia; Zhao, Pan; Tu, Zhenzhen; Chen, Xianguo; Di, Lijun; Zhou, Haisheng; Zhang, Hongbing
• Is Part Of: Cancer letters. Volume 359:Issue 1(2015)
• Page Start: 97
• Page End: 106
• Publication Date: 2015-04-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.01.001
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">TSC1/TSC2 complex is a negative regulator of Glut3.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Loss of TSC1/TSC2 complex up-regulates the expression of Glut3 through the activation of mTORC1 signaling.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">mTORC1 up-regulates Glut3 via the activation of the IKK/NFκB signaling pathway.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Attenuation of Glut3 inhibits oncogenic mTOR-mediated glycolysis and tumorigenesis.</p> </list-item> </list> </p> </sec> </abstract>