Suggestive evidence on the involvement of polypyrimidine-tract binding protein in regulating alternative splicing of MAP/microtubule affinity-regulating kinase 4 in glioma. Issue 1 (1st April 2015)

• Record Type: Journal Article
• Authors: Fontana, L.; Rovina, D.; Novielli, C.; Maffioli, E.; Tedeschi, G.; Magnani, I.; Larizza, L.
• Is Part Of: Cancer letters. Volume 359:Issue 1(2015)
• Page Start: 87
• Page End: 96
• Publication Date: 2015-04-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.12.049
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">The centrosomal MARK4 kinase is mainly expressed as MARK4L in neural progenitors and as MARK4S in differentiated neurons.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">MARK4L isoform is highly expressed in glioma tissues and glioblastoma-derived cancer stem cells in absence of gene mutation.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Correlation of high levels of MARK4L and PTB in glioma tissues and glioblastoma-derived cancer stem cells.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Splicing minigene assay, EMSA and mass spectrometry point to a role of PTB in MARK4 alternative splicing in glioma.</p> </list-item> </list> </p> </sec> </abstract>