Targeting drivers of melanoma with synthetic small molecules and phytochemicals. Issue 1 (1st April 2015)

• Record Type: Journal Article
• Authors: Strickland, Leah Ray; Pal, Harish Chandra; Elmets, Craig A.; Afaq, Farrukh
• Is Part Of: Cancer letters. Volume 359:Issue 1(2015)
• Page Start: 20
• Page End: 35
• Publication Date: 2015-04-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.01.016
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p9010">Agents targeting members of the MAPK pathway have increased survival in patients with metastatic melanoma. </p> </list-item> <list-item id="u9015"> <label> </label> <p id="p9015">Combined therapy with agents that target members of the MAPK pathway has been shown to be superior to single agent. </p> </list-item> <list-item id="u9020"> <label> </label> <p id="p9020">Agents that target MAPK, PI3K and c-kit signaling pathways are currently being pursued both alone and in combination. </p> </list-item> <list-item id="u9025"> <label> </label> <p id="p9025">Phytochemicals inhibit signaling pathways with well-established roles in cell proliferation, survival and invasion.</p> </list-item> </list> </p> </sec> </abstract>