Knockdown of long non-coding RNA XIST exerts tumor-suppressive functions in human glioblastoma stem cells by up-regulating miR-152. Issue 1 (1st April 2015)

• Record Type: Journal Article
• Authors: Yao, Yilong; Ma, Jun; Xue, Yixue; Wang, Ping; Li, Zhen; Liu, Jing; Chen, Liangyu; Xi, Zhuo; Teng, Hao; Wang, Zhenhua; Li, Zhiqing; Liu, Yunhui
• Is Part Of: Cancer letters. Volume 359:Issue 1(2015)
• Page Start: 75
• Page End: 86
• Publication Date: 2015-04-01
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2014.12.051
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">LncRNA XIST expression was up-regulated in human glioblastoma stem cells (GSCs).</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Knockdown of XIST exerted tumor-suppressive functions in GSCs.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Knockdown of XIST suppressed tumor growth and produced high survival in vivo.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">There was reciprocal repression between XIST and miR-152.</p> </list-item> <list-item id="u0030"> <label></label> <p id="p0030">MiR-152 mediated the tumor-suppressive effects that knockdown of XIST exerted.</p> </list-item> </list> </p> </sec> </abstract>