Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases. (February 2015)

• Record Type: Journal Article
• Authors: Ciryam, Prajwal; Kundra, Rishika; Morimoto, Richard I.; Dobson, Christopher M.; Vendruscolo, Michele
• Is Part Of: Trends in pharmacological sciences. Volume 36:Number 2(2015)
• Page Start: 72
• Page End: 77
• Publication Date: 2015-02
• Subjects: Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2014.12.004
• Languages: English
• ISSNs: 0165-6147

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Widespread protein aggregation is observed in neurodegenerative diseases.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Supersaturated proteins form a metastable sub-proteome prone to aggregation.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Specific biochemical pathways are enriched in supersaturated proteins.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Supersaturated pathways are associated with neurodegenerative diseases.</p> </list-item> </list> </p> </sec> </abstract>